Mirati Therapeutics MRTX announced a non-exclusive deal with Verastem Oncology VSTM to conduct a clinical study on a combination of adagrasib, Mirati’s leading KRAS inhibitor candidate, and VS-6766, Verastem’s RAF/MEK inhibitor in KRAS G12C mutant non-small cell lung cancer (NSCLC).The phase I/II study will determine the maximum tolerated dose and recommend the dose for a phase II study and also study the safety, tolerability and efficacy of the combination in patients who have progressed on a KRAS G12C inhibitor. Mirati and Verastem will jointly oversee the study.In the year so far, the stock price of Mirati has declined 35.8% compared with the industry’s decline of 15.8%.Image Source: Zacks Investment ResearchMirati has initiated the submission of a new drug application (NDA) for adagrasib to treat patients with at least second-line NSCLC with KRAS G12C mutation, following prior systemic therapy. The company expects to complete the NDA submission by 2021-end.The KRYSTAL-1 study is evaluating adagrasib in multiple cohorts in combination with other therapies. These include a combination of adagrasib with Merck’s MRK Keytruda for first-line NSCLC, a combination of adagrasib plus Boehringer Ingelheim’s Gilotrif (afatinib) for advanced NSCLC and adagrasib combined with Lilly/Bristol-Myers’ BMY Erbitux for second-line colorectal cancer (“CRC”).Preliminary data from the adagrasib plus Merck’s Keytruda cohort demonstrated that the combination achieved 100% disease control rate with all seven patients exhibiting tumor regression ranging from 37% to 92% as of Oct 21, 2021.In September 2021, the company reported top-line data from a cohort of the study, which demonstrated that both adagrasib monotherapy and adagrasib+ Lilly/Bristol-Myers’s Erbitux achieved significant clinical activity and broad disease control in patients with KRAS G12C mutated CRC.A phase I/II combination study of adagrasib with Novartis' SHP2 inhibitor TNO-155 for advanced NSCLC and CRC is also currently ongoing.Several pipeline data readouts are expected in 2022, which could be catalysts for the stock.With regard to Verastem’s VS-6766, phase II studies are ongoing to evaluate VS-6766 in combination with defactinib in patients with recurrent low-grade serous ovarian cancer and patients with recurrent KRAS-G12V mutant NSCLC Mirati currently carries a Zacks Rank #3 (Hold). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here. Zacks' Top Picks to Cash in on Artificial Intelligence In 2021, this world-changing technology is projected to generate $327.5 billion in revenue. Now Shark Tank star and billionaire investor Mark Cuban says AI will create "the world's first trillionaires." Zacks' urgent special report reveals 3 AI picks investors need to know about today.See 3 Artificial Intelligence Stocks With Extreme Upside Potential>>Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Bristol Myers Squibb Company (BMY): Free Stock Analysis Report Merck & Co., Inc. (MRK): Free Stock Analysis Report Mirati Therapeutics, Inc. (MRTX): Free Stock Analysis Report Verastem, Inc. (VSTM): Free Stock Analysis Report To read this article on Zacks.com click here. Zacks Investment Research