Wall Street ended mostly higher on Monday as investor confidence got a boost after data from late-stage clinical trials of coronavirus vaccine from two drugmakers showed positive results. This sent the stocks rallying barring a few tech giants. The Dow Jones and S&P 500 posted sharp gains but fell shy of their records. However, the Nasdaq finished the day in red.How Did The Benchmarks Perform?The Dow Jones Industrial Average (DJI) gained 3% or 834.57 points to end the day at 29,157.97, marking its best day in terms of percentage gains since Jun 5. Notably, during the intraday session, the blue-chip index soared nearly 5.7% or more than 1,600 points to touch a fresh all-time high of 29,933.83, surpassing its previous all-time high of 29,568.57 recorded on Feb 12.The S&P 500 increased 1.17% or 41.06 points to close at 3,550.50. The Energy Select Sector SPDR (XLE) and Financials Select Sector SPDR (XLF), which were affected the most due to the coronavirus pandemic were the biggest gainers, gaining 14.3% and 8.2%, respectively. Seven out of eleven sectors of the benchmark index closed in positive territory.The tech-heavy Nasdaq dropped in the afternoon session to end the day in the red after declining 1.5% or 181.45 points to end at 11,713.78. The Big Tech were the biggest losers, with shares of Facebook, Inc. FB, Amazon,com, Inc. AMZN and Apple, Inc. AAPL, declining 5%, 5.1% and 2%, respectively. Amazon, Facebook and Apple each carries a Zacks Rank #3 (Hold). You can see the complete list of today's Zacks #1 Rank (Strong Buy) stocks here.The fear-gauge CBOE Volatility Index (VIX) was down 1.6% to 24.46. A total of 17.2 billion shares were traded on Monday, higher than the last 20-session average of 9.68 billion. Monday also witnessed the busiest trading session since June. Advancers outnumbered decliners on the NYSE by a 3.22-to-1 ratio. On Nasdaq, a 1.96-to-1 ratio favored advancing issues.Stocks Rally on Vaccine HopesOn Monday, drugmakers Pfizer, Inc. PFE and BioNTech SE BNTX said that their vaccine candidate showed positive results from their final-stage trail. The companies said that the vaccine candidate was found to be more than 90% effective. Although the vaccines are yet to be fully developed, the companies said that they are planning to submit the Emergency Use Authorization to the Food and Drug Administration soon. Shares of Pfizer and BioNTech gained 7.7% and 13.9%, respectively.This gave investor confidence a boost send stocks on a rally. Travel, energy, restaurant and hospitality companies which took the maximum beating following the coronavirus outbreak in March had one of the best sessions in a long time on Monday, following the announcement. Financial stocks also rallied on hopes of a quicker recovery of the economy.Besides, airline and cruise stocks also jumped following the announcement by Pfizer. Shares of Southwest Airline Company LUV jumped 9.7%, while shares of cruise operator Carnival Corporation & Plc CCL surged 39.3%.Tech Stocks Hit HardTech stocks which have had a rally since the coronavirus outbreak, were one of the biggest losers on Monday. Also, work-from-home stocks that were one of the biggest beneficiaries of the pandemic were hit hard, as vaccine hopes rose again. Shares of Zoom Video Communications, Inc. ZM declined 17.4%, while Netflix, Inc. NFLX plummeted 8.6%.Stocks That Made HeadlineDeutsche Bank Continues Revamping, To Sell IT Unit to TCSAs part of the planned transformation and moving ahead with its job-cutting target, Deutsche Bank AG DB has entered into an agreement with Tata Consultancy Services TCS to sell the bank’s technology services unit, Postbank Systems AG. (Read More)Goldman to Meet Strategic Targets, Remains on TrackAt the Bank of America BAC Future of Financials Virtual Conference 2020, Goldman Sachs GS chief financial officer Stephen Scherr noted that the bank is on track for meeting strategic targets planned earlier this year. (Read More)Biggest Tech Breakthrough in a GenerationBe among the early investors in the new type of device that experts say could impact society as much as the discovery of electricity. Current technology will soon be outdated and replaced by these new devices. In the process, it’s expected to create 22 million jobs and generate $12.3 trillion in activity.A select few stocks could skyrocket the most as rollout accelerates for this new tech. Early investors could see gains similar to buying Microsoft in the 1990s. Zacks’ just-released special report reveals 8 stocks to watch. The report is only available for a limited time.See 8 breakthrough stocks now>> Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Southwest Airlines Co. (LUV): Free Stock Analysis Report Amazon.com, Inc. (AMZN): Free Stock Analysis Report The Goldman Sachs Group, Inc. (GS): Free Stock Analysis Report Bank of America Corporation (BAC): Free Stock Analysis Report Apple Inc. (AAPL): Free Stock Analysis Report Carnival Corporation (CCL): Free Stock Analysis Report Pfizer Inc. (PFE): Free Stock Analysis Report Netflix, Inc. (NFLX): Free Stock Analysis Report Deutsche Bank Aktiengesellschaft (DB): Free Stock Analysis Report Facebook, Inc. (FB): Free Stock Analysis Report Container Store The (TCS): Free Stock Analysis Report BioNTech SE Sponsored ADR (BNTX): Free Stock Analysis Report Zoom Video Communications, Inc. (ZM): Free Stock Analysis Report To read this article on Zacks.com click here. Zacks Investment Research