Onconova Therapeutics, Inc. ONTX announced that it has commenced an investigator-initiated phase I/IIa study of oral rigosertib plus Bristol-Myers Squibb’s BMY Opdivo (nivolumab) in advanced metastatic KRAS mutated (KRAS+) lung adenocarcinoma.Rigosertib,Onconova’s lead candidate is a proprietary phase III small molecule. The candidatehas been tested in an intravenous formulation as a single agent for patients with higher-risk myelodysplastic syndromes (MDS) and an oral formulation as a single agent in lower-risk MDS or in combination with azacitidine for patients with higher-risk MDS.Opdivo is a prescription medicine used to treat people with a type of advanced-stage lung cancer called non-small cell lung cancer. Opdivo is a human IgG4 monoclonal antibody that blocks PD-1.The phase I investigator-initiated study will be followed by a phase IIa dose-expansion phase to study the combination of oral rigosertib and Opdivo in metastatic KRAS+ lung adenocarcinoma patients who have progressed on standard frontline treatment.The novel combination of rigosertib andOpdivo targets two of the most important oncogenic pathways in cancer biology. The study will evaluate the safety and tolerability of this combination in KRAS-mutated NSCLC, in which patients have failed frontline immunotherapy. The study will explore the efficacy of the combination in this common lung cancer subset and also determine if rigosertib may restore sensitivity to the PD-1 blockade.Shares of Onconova have surged 60.4% year to date against the industry’s decline of 4%.Onconova has a phase III clinical-stage product candidate . The company has two other clinical-stage product candidates (one of which has been studied for the treatment of acute radiation syndromes) and preclinical programs. Onconova Therapeutics, Inc. Price Onconova Therapeutics, Inc. price | Onconova Therapeutics, Inc. QuoteZacks Rank and Other Stocks to ConsiderOnconova is currently a Zacks Rank #2 (Buy) stock.Some other top-ranked stocks in the biotech sector are Amneal Pharmaceuticals Inc. AMRX and BioLineRx Ltd. BLRX, both carrying a Zacks Rank #1 (Strong Buy). You can see the complete list of today’s Zacks #1 Rank stocks here.Amneal’s earnings per share estimates have increased from 49 cents to 57 cents for 2020 and from 63 cents to 67 cents for 2021 in the past 60 days.BioLineRx’s loss per share estimates have narrowed from $2.77 to $2.24 for 2020 and from $3.01 to $2.88 for 2021 in the past 60 days.These Stocks Are Poised to Soar Past the PandemicThe COVID-19 outbreak has shifted consumer behavior dramatically, and a handful of high-tech companies have stepped up to keep America running. Right now, investors in these companies have a shot at serious profits. For example, Zoom jumped 108.5% in less than 4 months while most other stocks were sinking. Our research shows that 5 cutting-edge stocks could skyrocket from the exponential increase in demand for “stay at home” technologies. This could be one of the biggest buying opportunities of this decade, especially for those who get in early.See the 5 high-tech stocks now>>Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report BristolMyers Squibb Company (BMY): Free Stock Analysis Report BioLineRx Ltd. (BLRX): Free Stock Analysis Report Onconova Therapeutics, Inc. (ONTX): Free Stock Analysis Report AMNEAL PHARMACEUTICALS, INC. (AMRX): Free Stock Analysis Report To read this article on Zacks.com click here. Zacks Investment Research