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Not For The Faint Of CAR-T: The CAR-T Landscape In Early 2015

This is an extract from a longer report.

If you followed last year's explosion of enthusiasm in CAR therapies you might have assumed that this was a super-novel approach that had just burst onto the scientific stage. In fact work on the synthetic modification of a patient's T cells to make them target a specific disease has been ongoing for over 20 years.

But it is only relatively recently that two things happened: the CD19 antigen was pinpointed as an ideal target in haematological cancers thanks to its almost exclusive presence on B cells and B-cell precursors; and the current, so-called second-generation CAR (chimaeric antigen receptor) was designed.

This marked the transformation of CARs from just another interesting scientific concept to one of today's most promising oncology therapies. Progress has accelerated since the 2013 American Society of Hematology ((ASH)) meeting, and right now CAR therapy is already being hailed by… Read More …