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Celldex Therapy Extends Life for Those With Brain Cancer

Celldex Therapeutics Inc.’s cancer vaccine lengthened some patients’ lives in a midstage trial, potentially giving hope for treatment of a brain cancer that has no effective options for patients.

Five of the 36 patients with relapsed glioblastoma, a brain tumor, lived at least two years after starting therapy with Celldex’s treatment, known as Rintega, plus the cancer drug Avastin, the company said Friday in a statement. None of the patients who were taking Avastin alone lived that long.

Celldex shares jumped 17 percent to $16.95 at 2:52 p.m. in New York trading.

Rintega is a vaccine that primes the body to fight a form of glioblastoma that occurs in about one of three cases, according to David Reardon, a doctor at Dana-Farber Cancer Institute in Boston, who led the study. When patients who have the cancer are treated and it returns, there are no therapies that have been shown to lengthen life, Reardon...