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Prospectus [Rule 424(b)(5)]

The inform ation contained in this preliminary prospectus supplement and the accompanying prospectus is not complete and may be changed. A registration statement relating to the securities has been declared effective by the Securities and Exchange Commission. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell these securities and are not soliciting an offer to buy these securities in any jurisdiction where the offer or sale is not permitted.

Filed pursuant to Rule 424(b)(5)
Registration No. 333-197411

SUBJECT TO COMPLETION, DATED NOVEMBER 12, 2015

PRELIMINARY PROSPECTUS SUPPLEMENT

Shares

[GRAPHIC MISSING]

Alcobra Ltd.

Ordinary Shares

We are offering our ordinary shares. The offering price is $ per ordinary share. Our ordinary shares are listed on the NASDAQ Global Market under the symbol ADHD. On November 11, 2015, the last reported sales price of our ordinary shares on the NASDAQ Global Market was $7.51 per share.

We are an emerging growth company as defined under the federal securities laws and, as such, may elect to comply with certain reduced public company reporting requirements for future filings.

Investing in our ordinary shares involves a high degree of risk. Please read Risk Factors beginning on page S- 6 .

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

(1) The underwriters will also be reimbursed for certain expenses incurred in this offering. See Underwriting for details.

Delivery of the ordinary shares is expected to be made on or about , 2015. We have granted the underwriters an option for a period of 30 days to...


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