Celldex Therapeutics, Inc. (NASDAQ: CLDX) and Juno Therapeutics Inc (NASDAQ: JUNO) are two of last year's worst-performing biotech stocks. Both companies suffered upsetting
Luckily, both companies had additional candidates to pivot toward after their respective frontrunners crashed and burned. To see which of these cancer-focused drugmakers is the better buy right now, let's take a look forward to see how they compare.
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Celldex Therapeutics, Inc.: Strength in diversity
Celldex's stock cratered after its brain cancer vaccine Rintega failed to outperform standard chemotherapy in early 2016, and it hasn't quite recovered yet. Luckily, a return to pre-Rintega crash prices, or much higher, could be around the corner.
The company's new lead candidate, glemba, is a unique cancer therapy that attaches to a protein found on many tumor cell surfaces called gpNMB. Once inside the cell, it releases an ultra-lethal dose of chemotherapy.
Unlike Rintega, glemba had some evidence of a statistically significant benefit over standard chemo before Celldex decided to sponsor a large and expensive trial intended to support a new drug application. During a study with heavily pretreated breast cancer patients whose tumors overexpress glemba's target, a subset with an extremely difficult-to-treat form of the disease survived 166% longer without showing signs of disease progression than those receiving standard chemo. If glemba can repeat this success with similar patients in an...