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Statement of acquisition of beneficial ownership by individuals

> SCHEDULE 13G Amendment No. 5 VICAL INC COMMON STOCK Cusip #925602104 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [x] Rule 13d-1(b) [ ] Rule 13d-1(c) [ ] Rule 13d-1(d) Cusip #925602104 Item 1: Reporting Person - FMR LLC Item 2: (a) [ ] (b) [ ] Item 4: Delaware Item 5: 2,100 Item 6: 0 Item 7: 9,229,221 Item 8: 0 Item 9: 9,229,221 Item 11: 10.091% Item 12: HC Cusip #925602104 Item 1: Reporting Person - Edward C. Johnson 3d Item 2: (a) [ ] (b) [ ] Item 4: United States of America Item 5: 0 Item 6: 0 Item 7: 9,229,221 Item 8: 0 Item 9: 9,229,221 Item 11: 10.091% Item 12: IN Cusip #925602104 Item 1: Reporting Person - Abigail P. Johnson Item 2: (a) [ ] (b) [ ] Item 4: United States of America Item 5: 0 Item 6: 0 Item 7: 9,229,221 Item 8: 0 Item 9: 9,229,221 Item 11: 10.091% Item 12: IN Cusip #925602104 Item 1: Reporting Person - Select Biotechnology Portfolio Item 2: (a) [ ] (b) [ ] Item 4: Massachusetts Item 5: 5,921,845 Item 6: 0 Item 7: 0 Item 8: 0 Item 9: 5,921,845 Item 11: 6.474% Item 12: IV Item 1(a). Name of Issuer: VICAL INC Item 1(b). Address of Issuer's Principal Executive Offices: 10390 Pacific Center Court San Diego, CA 92121-4340 Item 2(a). Name of Person Filing: FMR LLC Item 2(b). Address or Principal Business Office or, if None, Residence: 245 Summer Street, Boston, Massachusetts 02210 Item 2(c). Citizenship: Not applicable Item 2(d). Title of Class of Securities: COMMON STOCK Item 2(e). CUSIP Number: 925602104 Item 3. This statement is filed pursuant to Rule 13d-1(b) or 13d-2(b) or (c) and the person filing, FMR LLC, is a parent holding company in accordance with Section 240.13d-1(b)(1)(ii)(G). (Note: See Exhibit A). Item 4. Ownership (a) Amount Beneficially Owned: 9,229,221 (b) Percent of Class: 10.091% (c) Number of shares as to which such person has: (i) sole power to vote or to direct the vote: 2,100 (ii) shared power to vote or to direct the vote: 0 (iii) sole power to dispose or to direct the disposition of: 9,229,221 (iv) shared power to dispose or to direct the disposition of: 0 Item 5. Ownership of Five Percent or Less of a Class. Not applicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person. Various persons have the right to...


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