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Statement of acquisition of beneficial ownership by individuals

> SCHEDULE 13G Amendment No. 0 2U INC COMMON STOCK Cusip #90214J101 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [x] Rule 13d-1(b) [ ] Rule 13d-1(c) [ ] Rule 13d-1(d) Cusip #90214J101 Item 1: Reporting Person - FMR LLC Item 2: (a) [ ] (b) [ ] Item 4: Delaware Item 5: 794,400 Item 6: 0 Item 7: 4,898,401 Item 8: 0 Item 9: 4,898,401 Item 11: 10.925% Item 12: HC Cusip #90214J101 Item 1: Reporting Person - Edward C. Johnson 3d Item 2: (a) [ ] (b) [ ] Item 4: United States of America Item 5: 0 Item 6: 0 Item 7: 4,898,401 Item 8: 0 Item 9: 4,898,401 Item 11: 10.925% Item 12: IN Cusip #90214J101 Item 1: Reporting Person - Abigail P. Johnson Item 2: (a) [ ] (b) [ ] Item 4: United States of America Item 5: 0 Item 6: 0 Item 7: 4,898,401 Item 8: 0 Item 9: 4,898,401 Item 11: 10.925% Item 12: IN Item 1(a). Name of Issuer: 2U INC Item 1(b). Address of Issuer's Principal Executive Offices: 8201 CORPORATE DRIVE SUITE 110 LANDOVER, MD 20785 USA Item 2(a). Name of Person Filing: FMR LLC Item 2(b). Address or Principal Business Office or, if None, Residence: 245 Summer Street, Boston, Massachusetts 02210 Item 2(c). Citizenship: Not applicable Item 2(d). Title of Class of Securities: COMMON STOCK Item 2(e). CUSIP Number: 90214J101 Item 3. This statement is filed pursuant to Rule 13d-1(b) or 13d-2(b) or (c) and the person filing, FMR LLC, is a parent holding company in accordance with Section 240.13d-1(b)(1)(ii)(G). (Note: See Exhibit A). Item 4. Ownership (a) Amount Beneficially Owned: 4,898,401 (b) Percent of Class: 10.925% (c) Number of shares as to which such person has: (i) sole power to vote or to direct the vote: 794,400 (ii) shared power to vote or to direct the vote: 0 (iii) sole power to dispose or to direct the disposition of: 4,898,401 (iv) shared power to dispose or to direct the disposition of: 0 Item 5. Ownership of Five Percent or Less of a Class. Not applicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person. Various persons have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of 2U INC. No one other person's interest in the COMMON STOCK of 2U INC is more than five percent of the total outstanding COMMON STOCK. Item 7...


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