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Regulation FD

On April22, 2016, Omeros Corporation, or the Company, filed with the U.S. Securities and Exchange Commission, or the SEC, the Companys proxy statement for its 2016 annual meeting of shareholders. This filing was also the remaining condition to effectiveness of the Companys Post-Effective Amendment No.2 to the Companys Registration Statement on

FormS-3

(File

No.333-201581)

filed by the company on March15, 2016. As a result, on April22, 2016 the Company filed with the SEC necessary updates to previously filed documents.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

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OMEROS CORPORATION

By:

/s/ Gregory A. Demopulos

Gregory A. Demopulos, M.D.

President, Chief Executive Officer and

Chairman of the Board of Directors

makes a similar move, sign up!

Other recent filings from the company include the following:

Omeros Corporation just filed a prospectus, suggesting it plans to soon issue some securities - April 22, 2016
Omeros Corporation just filed a prospectus, suggesting it plans to soon issue some securities - April 22, 2016
Omeros Corporation releases salary data. CEO sees compensation fall -82% - April 22, 2016
Omeros Corporation's VP Patent and General Counsel just cashed-in 15,900 options - April 15, 2016