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Transgenomic Reports Poster Presentation at CAP ’15 Highlighting Joint Project to Detect Actionable Mutations in Tumors from Metastatic Colorectal Cancer Patients

OMAHA, Neb.--(BUSINESS WIRE)--

Transgenomic, Inc. (TBIO)today announced that it presented a poster last week at CAP ’15, the annual meeting of the College of American Pathologists. The poster, which was co-authored by researchers from Transgenomic and Amgen, reported on the results of analysis of tumor tissue from two randomized clinical trials using Sanger sequencing. The analysis concluded that the use of validated assays, relevant controls, and assay-specific tissue requirements resulted in highly reproducible Sanger sequencing data from the FFPE clinical specimens.1

Transgenomic provided pharmacogenomic services that included identification of mutations in KRAS exons 3 & 4 / NRAS exons 2-4 (collectively, RAS) in more than 2000 metastatic colorectal cancer patients. The focus of this analysis was to determine whether accuracy of detection of RAS mutations is affected by analytical methods and sample preparation.

Katherine Richardson, PhD, Transgenomic Vice President of Research & Development, noted, “This multi-year project conducted with our colleagues at Amgen is a good example of how Transgenomic can work with our biopharmaceutical clients to generate data relevant to actionable mutations. In this project, we obtained...


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