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Actionable news in VRTX: Vertex Pharmaceuticals Incorporated,

Major indices mixed as UK begins Brexit

Stocks (^DJI, ^GSPC, ^IXIC) fluctuate following yesterday’s rally as good economic data rolls in, and the UK begins its divorce from Europe. Catch The Final Round at 4 p.m. with Justine Underhill and Yahoo Finance Editor-in-Chief Andy Serwer.

Winners and losers

Stocks getting hit today include Skechers on a Susquehanna downgrade citing increased competition in the footwear space, Dave & Busters as comparable restaurant sales missed street estimates. and Dunkin’ Brands – shares cooling off as Goldman isn’t liking what Dunkin’s brewing, downgrading it to ‘sell’ citing risks to sales growth.

Stocks getting a boost today include Vertex Pharmaceuticals on positive results for its cystic fibrosis...