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Actionable news in MDSO: Medidata Solutions, Inc.,

Statement of acquisition of beneficial ownership by individuals

> SCHEDULE 13G Amendment No. 2 MEDIDATA SOLUTIONS INC COMMON STOCK Cusip #58471A105 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [x] Rule 13d-1(b) [ ] Rule 13d-1(c) [ ] Rule 13d-1(d) Cusip #58471A105 Item 1: Reporting Person - FMR LLC Item 2: (a) [ ] (b) [ ] Item 4: Delaware Item 5: 57,891 Item 6: 0 Item 7: 5,611,153 Item 8: 0 Item 9: 5,611,153 Item 11: 10.134% Item 12: HC Cusip #58471A105 Item 1: Reporting Person - Abigail P. Johnson Item 2: (a) [ ] (b) [ ] Item 4: United States of America Item 5: 0 Item 6: 0 Item 7: 5,611,153 Item 8: 0 Item 9: 5,611,153 Item 11: 10.134% Item 12: IN Item 1(a). Name of Issuer: MEDIDATA SOLUTIONS INC Item 1(b). Address of Issuer's Principal Executive Offices: 350 Hudson St 9th Floor New York, NY 10014 USA Item 2(a). Name of Person Filing: FMR LLC Item 2(b). Address or Principal Business Office or, if None, Residence: 245 Summer Street, Boston, Massachusetts 02210 Item 2(c). Citizenship: Not applicable Item 2(d). Title of Class of Securities: COMMON STOCK Item 2(e). CUSIP Number: 58471A105 Item 3. This statement is filed pursuant to Rule 13d-1(b) or 13d-2(b) or (c) and the person filing, FMR LLC, is a parent holding company in accordance with Section 240.13d-1(b)(1)(ii)(G). (Note: See Exhibit A). Item 4. Ownership (a) Amount Beneficially Owned: 5,611,153 (b) Percent of Class: 10.134% (c) Number of shares as to which such person has: (i) sole power to vote or to direct the vote: 57,891 (ii) shared power to vote or to direct the vote: 0 (iii) sole power to dispose or to direct the disposition of: 5,611,153 (iv) shared power to dispose or to direct the disposition of: 0 Item 5. Ownership of Five Percent or Less of a Class. Not applicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person. Various persons have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of MEDIDATA SOLUTIONS INC. No one other person's interest in the COMMON STOCK of...


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