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Ionis Earns $10 Million Milestone Payment from Biogen for Advancing a New Program in its Neurology Collaboration

"We continue to make substantial progress in validating new targets and developing new drugs for neurological diseases using our antisense technology. SPINRAZA, the first drug to come out of our neurology collaboration with Biogen, exemplifies the potential of our antisense technology in the neurological disease space. To date, our collaboration with Biogen has generated a combined total of nearly $650 million," said B. Lynne Parshall, chief operating officer at Ionis Pharmaceuticals. "As we continue to advance our neurological disease pipeline, we look forward to bringing additional important medicines to patients suffering from neurodegenerative diseases."


Ionis and Biogen have a broad strategic collaboration combining Biogen's expertise in neurology with Ionis' leadership in antisense technology to develop novel therapies to treat neurological disorders. Ionis is primarily responsible for drug discovery and early development of antisense therapies. Biogen has the option to license each antisense program at a particular stage in development. Under this collaboration, Ionis developed and licensed SPINRAZA to Biogen. SPINRAZA is approved in the U.S., EU, Japan and Canada for the treatment of patients with spinal muscular atrophy (SMA). Also under this collaboration, Ionis and Biogen are developing IONIS-SOD1Rx to treat amyotrophic lateral sclerosis, IONIS-MAPTRx to treat Alzheimer's Disease, and IONIS-BIIB5Rx...