Gainers Synergy Pharmaceuticals Inc shares rose 11.11 percent to $3.70 in pre-market trading after the company reported the NDA acceptance for Plecanatide by the FDA. Harley-Davidson Inc rose 5.86 percent to $49.70 in pre-market trading after the company reported better-than-expected Q1 earnings. SolarCity Corp shares rose 3.97 percent to $31.45 in pre-market trading after gaining 4.17 percent on Monday. Tile Shop Hldgs, Inc. rose 3.76 percent to $16.55 in pre-market trading after the company reported stronger-than-expected Q1 earnings and raised its FY forecast. UnitedHealth Group Inc rose 1.96 percent to $130.32 in pre-market trading after the company reported upbeat quarterly earnings and lifted its FY outlook. Spirit Airlines Incorporated shares rose 1.90 percent to $51.00 in pre-market trading following an update to its first quarter guidance. Spirit Airlines updated its operating margin guidance for the quarter to approximately 21.5 percent, up from a previous guidance range of 19.0 to 20.5 percent. Find out what's going on in today's market and bring any questions you have to Benzinga's PreMarket Prep.Losers Applied Optoelectronics Inc shares fell 20.98 percent to $12.73 in pre-market trading after the company reported preliminary first quarter results which mostly fell short of prior guidance. Applied Optoelectronics now expects to lose $0.04 to $0.06 per share on revenue $50 million to $50.5 million. The company previously guided its earnings per share to a range of $0.21 to $0.28 on revenue of $50 million to $54 million. Illumina, Inc. shares fell 18.04 percent to $145.99 in pre-market trading after the company issued a weak revenue forecast for the first quarter. Bank of America downgraded Illumina from Buy to Neutral. Rambus Inc. shares fell 13.80 percent to $11.87 in pre-market trading. Rambus reported upbeat earnings for the first quarter, but the company issued a weak revenue forecast for the second quarter. Netflix, Inc. shares fell 8.97 percent to $98.68 in pre-market trading. Netflix reported better-than-expected earnings for the first quarter, but the company missed analysts’ sales estimates. The company also issued a weak guidance for the second quarter. International Business Machines Corp. shares fell 4.53 percent to $145.69 in pre-market trading. IBM reported stronger-than-expected results for its first quarter on Monday. eBay Inc shares fell 3.20 percent to $24.50 in pre-market trading. Morgan Stanley downgraded eBay from Equal-weight to Underweight and lowered the price target from $24.00 to $22.50. Read more: http://www.benzinga.com/news/16/04/7855503/12-stocks-moving-in-tuesdays-pre-market-session#ixzz46H6S587c