The Corbus Pharmaceuticals (
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(You met this investor and Corbus bear in October, when I wrote a
Corbus shares closed Monday 51% higher to $8.85 on the announcement of the resunab phase II results in systemic sclerosis, an autoimmune disease that causes the accumulation of fibrotic tissue under the skin and in the lungs. At one point Monday, the market value of Corbus almost doubled but the stock sold off later in the day.
The sclerosis patients treated with resunab reported a median 33% response rate over the 16 weeks of the trial compared to a median 0% response rate for placebo patients, achieving the primary endpoint with statistical significance, Corbus said.
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On a conference call Monday morning, the doctor who acted as the principal investigator of the study described the resunab results as "breathtaking."
Why shouldn't these results be trusted? Because the sclerosis patients who received resunab were healthier at the start of the trial compared to the patients treated with placebo, Corbus' own data show.
The imbalances in patient baseline characteristics provided an assist to the resunab treatment response and undermines the credibility of the trial results, my investor source said.
You don't have to believe him, of course. Corbus, to its credit, provided investors with enough data from the trial for them to make up their own minds. Slides from Corbus' resunab data presentation can be downloaded
The Corbus study enrolled 43 sclerosis patients, randomized 2:1 to receive resunab or placebo.
On average, the a>