Actionable news
All posts from Actionable news
Actionable news in CDTX: Cidara Therapeutics Inc,

Cidara Therapeutics Presents Results from Key Studies Evaluating Its Novel Echinocandin CD101 at ICAAC/ICC 2015

SAN DIEGO--(BUSINESS WIRE)--Cidara Therapeutics, Inc. (Nasdaq:CDTX), a biotechnology company developing novel anti-infectives and immunotherapies to treat fungal and other infections, today announced the presentation of preclinical data from studies demonstrating the unique attributes of Cidara’s lead antifungal drug candidate, CD101, supporting its potential use for treating serious fungal infections. The results are being presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) and the International Congress of Chemotherapy (ICC) joint meeting in San Diego, September 17-21, 2015.

“Data presented at this year’s ICAAC/ICC meeting establish the breadth, depth and promise of our antifungal drug development program”

Tweet this

A total of three oral presentations and 14 posters presented at ICAAC/ICC 2015 highlight results from a broad range of preclinical studies evaluating Cidara’s investigational programs for CD101 IV, CD101 Topical and the Cloudbreak™ targeted immunotherapy platform. The majority of these presentations focus on CD101 IV, providing a description of the compound’s novel design and resulting benefits that differentiate it from first-generation echinocandins. The preclinical studies demonstrate that CD101 is associated with high stability and solubility, potent antifungal activity with high efficacy in animal models, and no toxicity signals.

“Data presented at this year’s ICAAC/ICC meeting establish the breadth, depth and promise of our antifungal drug development program,” said Jeff Stein, Ph.D., president and CEO of Cidara. “We anticipate that the unique attributes of CD101 will translate into a safe, effective and long-acting echinocandin that could benefit patients in fighting both systemic and local fungal infections. We are extremely pleased that data presented this week support this expectation.”

There is a significant unmet need for novel drugs to treat fungal infections associated with high mortality rates and rising drug resistance, typically affecting patients whose immune systems have been compromised. In the United States alone there are an estimated 97,000 deaths per year among patients with hospital-related fungal infections, and nearly 90 percent of these infections are caused by two fungi, Candida and Aspergillus. CD101 IV is currently in Phase 1 clinical development and was recently designated a Qualified Infectious Disease Product (QIDP) with Fast Track status from the U.S. Food and Drug Administration (FDA) for the treatment of candidemia and invasive candidiasis.

“Current antifungal standards of care, including first-generation echinocandins, have multiple limitations, including inconvenient daily IV dosing and dose-limiting toxicities,” said Dirk Thye, M.D., chief medical officer of Cidara. “We are committed to...