Dr. Phillip Frost is the CEO of Opko Health (
He's also a fearless microcap investor.
Through four investment vehicles he controls, Frost has invested $212.8 million in 72 different private-investment-in-public-equity transactions since 2005, according to PrivateRaise, The Deal's data base that tracks PIPEs. While many of those investments are in biotech or healthcare, plenty of them are microcaps, some of those trading over the counter.
The latest PIPE transaction found Frost Gamma Investments Trust investing an undisclosed amount in Drone Aviation Holding (
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Frost Gamma was also an investor in a reverse merger that closed Oct. 24 involving Tiger X Medical and BioCardia (
A merger filing showed that Frost now owns 32.7% of BioCardia, a San Carlos, Calif-based clinical-stage company focused on developing treatments for cardiovascular diseases. It is traded on the OTCPK platform and traded at 15 cents on Friday.
The 80-year-old Frost calls Star Island in Florida's Miami Beach home, on property that was formerly owned by the businesswoman Leona Helmsley. He made his fortune in biotechnology beginning with purchasing Key Pharmaceuticals along with Michael Jaharis in an all-stock deal in 1972. They sold the company 14 years later for $800 million to Schering-Plough. Frost's take was $100 million.
Next, he was at the helm of Ivax for almost two decades, exploiting overseas markets with sales of generic drugs before other...