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ZS Pharma: 47 Am ZS Employees Subject:

The following excerpt is from the company's SEC filing.

Message from Pascal Soriot

Hi Everybody:

I just got this email from Pascal and he asked that I forward it on to all of you.

Have a great weekend!


Subject: Message from Pascal Soriot, CEO AstraZeneca

Dear all,

Following todays announcement, I wanted to share why I am so excited by the agreement that I hope will see ZS Pharma soon join AstraZeneca.

Cardiovascular and metabolic disease is one of AstraZenecas main therapy areas and ZS Pharma will have an extremely important role to play in working with us to achieve our core purpose: to push the boundaries of science to deliver life-changing medicines.

As you know, cardiovascular and metabolic disease affects hundreds of millions of people around the world and there is high unmet medical need. AstraZeneca has been driving innovation in this space for more than 100 years and we are committed to reducing morbidity, mortality and organ damage by addressing multiple risk factors across cardiovascular disease, diabetes and chronic kidney disease. You are making a great contribution to developing an innovative treatment to address one of them hyperkalaemia, a leading cause of mortality in patients suffering from chronic kidney disease and chronic heart failure. The alignment with our work at AstraZeneca is clear.

At AstraZeneca we share your entrepreneurial mindset, commitment to science and passion to make a difference. By combining the expertise, know-how and capabilities of ZS Pharma with AstraZenecas existing teams and portfolio of innovative medicines, we will together be in a stronger position to make an even bigger difference in the lives of many people around the world.

Whats more, you will be joining AstraZeneca at a tremendously exciting time we have built one of the most promising pipelines in the industry and we are rapidly accelerating its delivery. I had the pleasure of announcing our third quarter and nine months results only yesterday and we once again reported strong scientific and commercial progress. With ZS Pharma joining...