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Actionable news in PFE: PFIZER Inc,

Pfizer said to be in talks with Allergan to forge $330 bln drugs giant

* Drug companies have held early talks, WSJ and FT say

* Merger would create world's biggest healthcare group

* Pfizer and Allergan decline to comment (Adds Pfizer no comment, further analyst reaction, GSK/Shire share price falls)

By Natalie Grover and Christian Plumb

Oct 28 (Reuters) - Pharmaceutical giant Pfizer Inc has held early talks with Botox-maker Allergan Plc to discuss what could be the biggest takeover deal this year, the Wall Street Journal and Financial Times reported.

The healthcare sector has seen an unprecedented wave of deals since early 2014, from large drugmakers buying up smaller rivals, to consolidation among makers of generic medicines and tie-ups between insurers.

A bid for Allergan, which has a market value of $113 billion, would be Pfizer's second recent attempt to acquire a big rival, following its unsuccessful courtship last year of Anglo-Swedish pharmaceuticals group AstraZeneca Plc.

Combining Allergan and Pfizer, which is worth $219 billion, would create the world's largest healthcare group with a market value of around $330 billion, ahead of Johnson & Johnson on $278 billion.

A Pfizer spokesman said it "does not comment on market rumour and speculation". Allergan also declined to comment.

The potential for lowering Pfizer's tax bill by switching its...


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